Design and evaluate moleculeswith manufacturability in mind.
Design siRNA / ASO / mAb / biosimilar / BsAb leads, then evaluate developability — all in one platform, with synthesis and purification in view. Avoid the 6-month CMC restart.
| # | Candidate | Score |
|---|---|---|
| 1 | siPCSK9-12 | 9.2 |
| 2 | siPCSK9-08 | 9.0 |
| 3 | siPCSK9-17 | 8.7 |
| 4 | siPCSK9-04 | 8.5 |
| 5 | siPCSK9-15 | 8.3 |
By the time you find out, you've already spent millions.
A molecule looks perfect in Discovery. Target hit. Strong affinity.
Then it enters CMC — it aggregates. It is hard to purify. PTM hot spots everywhere. Solubility at clinical dose is too low.
The team restarts 6 months later. Most of this could have been predicted from the sequence.
Catch it on the screen, not in the lab.
InAnvil evaluates molecules in 30 seconds across 8 developability dimensions — before you commit to a chemistry route, before you commission a CRO, before you start a tank.
Design + Evaluation, one platform.
11 submodules across mAb · ADC · oligo · biosimilar · BsAb — design and developability evaluation.
D1 · siRNA Lead Design
Gene + species + chemistry → 10–20 ranked candidates with modifications, off-target check, synthesis cost, recommended purification.
D2 · ASO Lead Design
Same plus gapmer / SSO / blocker type → ASO candidates with MOE / LNA wing and CpG screening.
D3 · mAb Humanization + Affinity + Liability
Murine VH/VL → humanized sequence, humanness score, liability report.
D4 · Biosimilar reverse design
Reference biologic + target market → CMC strategy, patent risk map, CQA alignment.
D5 · Bispecific Design
Two targets + mechanism → format recommendation, full sequence, expression yield, CMC complexity.
Built on best-in-class research tools.
We don't reinvent the wheel for prediction. We integrate the academic and industry tools that work — and calibrate them with Inscinstech's own CMC data.
From scored to scaled.
Pass a scored molecule directly to InForge. It picks up the recommended purification route and starts process design — with your team's history and preferences pre-loaded.
Three teams. Three quarters saved.
“We screen 50 candidates a year. Used to ship 5 bad ones to CMC. Now we ship 5 of the best 5.”
“InAnvil cut our 'molecule rejected after 3 months' incidents by 70% in Year 1.”
“When a client sends a sequence + InAnvil report, we quote 30% faster and more accurately.”
InAnvil at every tier.
Read-only evaluation. Your sequences stay yours.
A full developability scorecard.
| Agg | Visc | Sol | PTM | Pur | Form | Char | Imm | ||
|---|---|---|---|---|---|---|---|---|---|
| mAb-001 | 8.2 | ||||||||
| mAb-002 | 6.4 | ||||||||
| mAb-003 | 9.1★ | ||||||||
| mAb-004 | 3.8 | ||||||||
| mAb-005 | 8.7 |
Common questions
Score a molecule. Save a quarter.
5 free mAb developability scores per month. No credit card.