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INCORTEX · CMC PROCESS PLATFORM

Your CMC knowledge. Productized.

Process development assistant trained on Inscinstech's v2.2 CMC knowledge base, FDA review documents, and your own historical batches. 21 CFR Part 11-ready.

Free to start · upgrade any time
mAb-003 · Purification process · v0.3DoE-backed
CAPTURE
Protein A
MabSelect · pH 7.4 · DBC 50 g/L
load 42 g/L
POLISH
CEX
Capto S · pH 5.1 · NaCl 200 mM
DoE optimum
VIRAL
Low-pH hold
pH 3.5 · 30 min · + 20 nm filter
≥ 6 LRV
FINAL
UF/DF
Pellicon 3 · 30 kDa · Buffer A
50 mg/mL
Predicted CQAs
78%Yield
0.3%HMW
12 ppmHCP
≥6Viral LRV
✓ Audit trail✓ 21 CFR Part 11 signature ready
01THE PROBLEM

CMC knowledge is tribal — and that's the problem.

Every process scientist carries 10 years of habits, preferences, unwritten rules.

When they leave, that knowledge leaves with them. When a new molecule arrives, half the team relearns it.

What if the knowledge stayed?

02THE SOLUTION

A copilot trained on real CMC.

InCortex absorbs Inscinstech's CMC v2.2 knowledge base (82+ entries), FDA review docs, and your team's batch records — as a process design copilot.

03CAPABILITIES

Five workflows across the CMC lifecycle.

From the initial process tree to the final IND/NDA document draft.

P0 · CORE

Process development assistant

User describes the molecule + target; the Agent recommends a process across capture / polish / viral / final steps — with resin, buffer, parameter ranges, risk flags, and alternatives per step. Backed by a real chromatography-column catalog and multi-tenant process records.

TIER · Pro+
P1

DoE design · execution · analysis

Live DoE workspace backed by a Gaussian-process + active-learning microservice: factors / responses, response surface, and a recommended next run. Writes to an auditable process record.

TIER · Pro+
P2

Impurity attribution + method development

Upload HPLC / MS data; the Agent attributes impurity sources (OligoMS approach) and recommends characterization methods + limits.

TIER · Plus+
P3

Risk assessment + ICH Q9 automation

FMEA / Risk Assessment templates + AI fill, outputs IND/NDA report drafts.

TIER · Plus+
P4

CMC document drafting

Development report · Process description · Specification draft generation, FDA / NMPA style-matched.

TIER · Plus+
P5

Competitive & pipeline intelligence · scheduled digests

Track a related company’s development pipeline and summarize updates as they land; compile a weekly industry-trend digest. One of the scheduled-task types — runs in the background and delivers to you on cadence.

TIER · Free+
04COMPLIANCE

GxP-ready from day one.

We didn't add compliance as an afterthought. It's a primary engineering constraint.

21 CFR Part 11 compliant electronic records and signatures
Immutable audit trail (Temporal-backed long workflows)
Role-based access control (RBAC) per project, per stage
Customer data never trains the model (contractually guaranteed)
Private deployment available (on customer infrastructure)
IBS integration for accounts, billing, audit
No internet exfiltration in private deployment mode
05USE CASES

Three roles. Three force multipliers.

CM
CMC manager

Turns the P-2 → P-3 transition from trial-and-error into a few evidence-backed DoE rounds.

Internal process-dev pilot · target scenario
PS
Senior process scientist

InCortex drafts the dev report; I spend my time on the decisions and the review.

Internal process-dev pilot · target scenario
CR
CRO CMC lead

A small team punches above its weight — InCortex keeps accumulated process know-how at hand.

Internal process-dev pilot · target scenario
06SAMPLE OUTPUT

An InCortex process design.

app.inscinstech.ai
mAb-003 · Purification process · v0.3DoE-backed
CAPTURE
Protein A
MabSelect · pH 7.4 · DBC 50 g/L
load 42 g/L
POLISH
CEX
Capto S · pH 5.1 · NaCl 200 mM
DoE optimum
VIRAL
Low-pH hold
pH 3.5 · 30 min · + 20 nm filter
≥ 6 LRV
FINAL
UF/DF
Pellicon 3 · 30 kDa · Buffer A
50 mg/mL
Predicted CQAs
78%Yield
0.3%HMW
12 ppmHCP
≥6Viral LRV
✓ Audit trail✓ 21 CFR Part 11 signature ready
07FAQ

Common questions

In private mode, InCortex runs on your infrastructure (Kubernetes / VM). No telemetry. No external model calls unless you configure them. Audit logs stay on-prem.
No — it gives them leverage. Drafts come from InCortex; decisions, risk acceptance, and final sign-off come from your team. The audit trail records who approved what.
Inscinstech CMC v2.2 (82+ entries spanning capture, polishing, viral safety, filtration, formulation) plus a public corpus of FDA review documents. Your team's batch records layer on top — never shared.
Yes — IBS is supported natively (accounts / billing / audit). LIMS via standard API integration on Enterprise.
Want the full picture?Explore InCortex features

Stop relearning what you already know.

Start free — upgrade to Pro / Plus / Max any time.

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InCortex · CMC process-development platform | inscinstech.ai